CBD also behaves as an agonist of the TRPV1 , the receptor associated with the analgesic benefit of capsaicin in neuropathic pain, suggesting another mechanism for its action against nerve pain. As a result this may lead to elevated blood levels of these medications and their associated side effects. Other drugs including indomethacin , diazepam and propranolol . Medications with anticholinergic activity such as amitriptyline and doxepin, and muscle relaxers such as cyclobenzaprine may increase the psychoactive side effccts of cannabinoids.
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